In collaboration with epidemiologists and biostatisticians, we have been carrying out molecular epidemiological studies by taking advantage of resources provided by cancer registries, to study the association of genetic variants with breast cancer risk. We have currently investigating the role of over 100 SNPs in breast cancer risk using high-throughput genotyping technologies and DNA pooling strategies. These SNPs are selected from various cancer related pathways. In addition to risk contribution by individual SNPs, we are also interested in determining the impact of multiple SNPs affecting cancer risk in concert.